November 26, 2023
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# What Supplements Does David Sinclair Take?

David Sinclair is a well-known professor of genetics at Harvard Medical School, and he is also the co-director of the Paul F. Glenn Center for the Biology of Aging Research at Harvard. He has dedicated his career to studying the molecular mechanisms of aging and how it can be slowed or even reversed. In addition to his research, he is also an advocate for healthy living and takes various supplements to support his health and longevity.

Here are some of the supplements that David Sinclair takes:

## 1. Nicotinamide Riboside (NR)

NR is a form of vitamin B3 that is found in small amounts in milk. It is a precursor to nicotinamide adenine dinucleotide (NAD+), a molecule that plays a key role in energy metabolism and cellular repair. Studies have shown that NR supplementation can increase NAD+ levels in the body, which can have numerous health benefits, such as improving mitochondrial function, promoting healthy aging, and reducing inflammation. Sinclair himself has been taking NR for over a decade and believes that it is one of the most important supplements for longevity.

## 2. Resveratrol

Resveratrol is a polyphenol compound found in grapes, red wine, and some berries. It is a well-known antioxidant that has been shown to have anti-inflammatory and anti-cancer properties. In addition, it can activate sirtuins, a group of proteins that play a role in aging and longevity. Sinclair has been studying resveratrol for many years and has found that it can improve mitochondrial function and increase lifespan in some animal models.

## 3. Metformin

Metformin is a drug that is commonly used to treat type 2 diabetes. It works by reducing glucose production in the liver and improving insulin sensitivity. However, it has also been shown to have potential anti-aging effects, such as reducing inflammation, improving mitochondrial function, and activating AMPK, a protein that plays a role in cellular energy homeostasis. Sinclair has been taking metformin for several years and believes that it can help to prevent age-related diseases and improve overall health.

## 4. Vitamin D3

Vitamin D3 is a fat-soluble vitamin that is produced by the skin when exposed to sunlight. It plays a key role in bone health, immune function, and calcium absorption. However, many people are deficient in this vitamin, especially during the winter months or if they live in northern latitudes. Sinclair takes a daily dose of vitamin D3 to ensure that his levels are optimized.

## 5. Omega-3 Fatty Acids

Omega-3 fatty acids are essential fats that are found in fish, nuts, and seeds. They play an important role in brain function, heart health, and inflammation. Sinclair takes a daily dose of omega-3 fatty acids to help support his brain function and reduce the risk of age-related cognitive decline.

## 6. Curcumin

Curcumin is a compound found in turmeric, a spice commonly used in Indian cuisine. It has potent anti-inflammatory and antioxidant properties and has been shown to have potential benefits for a wide range of health conditions, such as arthritis, depression, and Alzheimer’s disease. Sinclair takes a daily dose of curcumin to help reduce inflammation in his body.

In conclusion, David Sinclair is a strong advocate for healthy living and takes various supplements to support his health and longevity. These supplements include nicotinamide riboside, resveratrol, metformin, vitamin D3, omega-3 fatty acids, and curcumin. While these supplements may not be suitable for everyone, they may offer potential benefits for those who want to improve their overall health and reduce the risk of age-related diseases.

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