November 28, 2023
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What Supplements Should Not Be Taken With Entresto?

Your doctor may check the levels of B-type natriuretic peptide (BNP) or NT-proBNP in your blood, two chemicals produced by your heart that increase when its condition worsens.

Entresto contains two drugs, sacubitril and valsartan, that work differently. Sacubitril belongs to a class of drugs called neprilysin inhibitors; it blocks an enzyme in your body responsible for breaking down peptides into smaller components that help drain sodium and fluid from your system. Valsartan works differently by increasing sodium removal.


Entresto is a combination of sacubitril and valsartan drugs used to treat heart failure in adults. This treatment reduces mortality risk, hospitalization costs and blood pressure by lowering it significantly. While taking Entresto, be sure to adhere to your doctor’s recommendations regarding fluid intake and low sodium diet, along with any prescribed supplements or other medications as taking other medicines could increase risks significantly – if taking other medicines simultaneously is necessary please notify both doctor and pharmacist beforehand as it could have harmful side effects.

Entresto’s active ingredients alter the delicate hormone system that regulates body fluid levels. This may result in reduced kidney function affecting around five percent of patients; eventually this could progress into renal failure, necessitating dialysis or transplantation as soon as possible. Your physician will monitor your kidney health while on Entresto.

Valsartan may exacerbate existing kidney conditions in those already suffering, and may increase potassium levels to potentially fatal levels if taken in combination with diuretics that don’t flush potassium out, heavy drinking, or both. Your physician should regularly evaluate your kidney function while on Entresto.

Your doctor will likely start you on a low dose of Entresto (49/51) twice daily and gradually increase it until a maintenance dose has been reached. Your urine may also be tested for protein to ensure no kidney damage has occurred.

If you are having difficulty swallowing tablets, your pharmacist can combine crushed tablets with liquid and mix the result as an oral suspension for you to drink. This liquid form can then be consumed via spoon or measuring cup; its name being an “oral suspension.” It comes in two strengths – 49/51 mg and 97/103 mg; their inactive ingredients being microcrystalline cellulose, low-substituted hydroxypropylcellulose, crospovidone, magnesium stearate from vegetable sources and talc. Additionally, 49/51 mg tablets contain iron oxide red and titanium dioxide while their film-coat while those for 97/103 mg contain iron oxide black.


Entresto should only be used with specific minerals to reduce the risk of drug interactions, especially if taken alongside medication for high blood pressure, diuretics (water pills), or antacids that contain magnesium or aluminum. Please consult your healthcare provider prior to beginning or stopping any medications while on Entresto.

If you take antacids, avoid taking Entresto within one hour prior or after, as this combination could cause low blood pressure, dizziness and affect heart failure medications. If taking both drugs together, inform your physician immediately if symptoms such as lightheadedness or dizziness arise;

Entresto is an innovative prescription medication that combines an angiotensin receptor blocker and neprilysin inhibitor to aid people suffering from heart failure by lowering high blood pressure, improving circulation to the heart, and decreasing fluid retention in the body. This combination works by widening blood vessels for increased blood flow while simultaneously decreasing fluid accumulation in your system.

Entresto should not be taken if you are allergic to sacubitril, valsartan or any of its ingredients. In addition, you should also refrain from taking it if you have kidney or liver conditions, diabetes or hereditary angioedema in your family history.

Before beginning Entresto treatment, make a comprehensive list of all the medications and supplements you are currently taking – this should include both prescription and over-the-counter medicines, vitamins, dietary supplements, herbal products as well as any pregnant or nursing moms planning pregnancy or breastfeeding plans. Furthermore, keep all appointments with doctors or lab technicians during this treatment time period.

Herbal Supplements

Many herbal supplements are promoted as natural and safe, yet they can have powerful impacts on the body and interact with prescribed medications in unpredictable ways, potentially causing side effects or exacerbating certain medical conditions. Some can interfere with drugs used to treat cardiovascular issues like high blood pressure and heart failure.

Entresto (sacubitril/valsartan) is a prescription medication prescribed to adults suffering from chronic heart failure with left ventricular ejection fraction below normal, to reduce their risk of cardiovascular death and hospitalization. Additionally, this drug may also be prescribed for treating heart failure in children aged one year old or over.

Common side effects of this medication may include low blood pressure, dizziness, and fainting. If these occur for you, please notify your physician as soon as possible so they can adjust or switch you over to another drug as soon as possible.

Low blood pressure can be particularly hazardous when taken alongside other drugs that also reduce it, such as diuretics. Furthermore, it’s essential that you notify your physician if you have hereditary angioedema or severe liver disease.

This medication may increase potassium levels in your blood, which is a potentially serious side effect that could even prove life-threatening. If this happens while taking this drug, your physician will likely adjust or stop giving you dosage or discontinue use temporarily.

Kidney function may become impaired with this medication, particularly among elderly patients with kidney or heart failure. Therefore, it’s essential to inform your healthcare provider or pharmacist if you have high blood pressure, diabetes or kidney or liver disease before beginning Entresto. Your healthcare provider may conduct laboratory tests to monitor both kidney function and potassium levels while on this treatment.

Be sure to provide your doctor with an accurate list of all medications you are currently taking, such as herbs, vitamins, dietary supplements and any other treatments – including herbal medicines, vitamins, dietary supplements and any other forms of treatment – including herbs and supplements such as Entresto. This will help avoid adverse drug interactions. Also inform them if you are pregnant or breastfeeding since taking Entresto during this time could endanger both you and your unborn baby.

Dietary Supplements

Entresto is used to treat heart failure in those with reduced ejection fraction, where lower chambers don’t pump out enough blood. The drug works by inhibiting B-type natriuretic peptide (BNP) breakdown and blocking an enzyme responsible for breaking down NT-proBNP, both natural substances produced by your heart during cardiopulmonary exercise or heart attacks; their levels serve as indicators as to whether or not your heart remains healthy.

As this medication may increase the risk of adverse side effects to unborn babies and cause kidney issues, pregnant and breastfeeding women should not take it. Furthermore, taking it in combination with certain other drugs may impair its efficacy; your physician will order certain blood tests prior to starting you on this treatment and monitor kidney and liver functions during your regimen. In case any issues arise from taking this drug, dose reduction or switch may be advised accordingly.

Some people who take Entresto experience a cough; this should go away once you discontinue taking the drug, though if your low blood pressure persists it should be reported immediately to your physician who may suggest taking diuretics (water pills) and/or decreasing your dosage of Entresto.

An angioedema allergic reaction may occur when taking Entresto. If an angioedema develops, symptoms include swelling in your eyes, mouth, nose or throat that blocks airways requiring immediate medical intervention and care. If this happens to you it’s important that you contact either your doctor immediately or the nearest hospital emergency department as soon as possible for medical help.

Potassium levels may increase when taking this medication, potentially placing your heart at risk. Potassium can be found in various dietary supplements designed to treat high blood pressure or cholesterol; beverages and foods like fruit juices and soups contain potassium; as do vegetables such as asparagus, fennel and spinach that contain it.

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