April 20, 2024
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what supplements to avoid while on eliquis

Eliquis, known generically as apixaban, is a prescription blood thinner that helps prevent harmful blood clots. It is important to understand how it interacts with other medications, supplements, and over-the-counter products before starting treatment.

Your doctor may not prescribe it if you have an artificial heart valve, certain clotting disorders, or active bleeding. You should also avoid it if you have triple-positive antiphospholipid syndrome (APS), which can increase your risk of blood clots.

Vitamin D

A nutrient that helps regulate many critical cellular functions, vitamin D aids calcium absorption to prevent osteoporosis and fractures; regulates cells responsible for autoimmune function; fights inflammation and disease-causing germs; creates a healthy gut microbiome and is linked to improved heart health. Vitamin D also acts as an anticoagulant, helping to thin the blood and prevent harmful clots.

Unlike warfarin, the active ingredient in Eliquis does not depend on vitamin K-dependent clotting pathways and therefore is not affected by intake of foods high in Vitamin K, such as spinach, broccoli, kale and brussels sprouts. However, it is important to talk with your doctor about any food or supplements you are taking and to monitor your INR (international normalized ratio) level closely for the first few weeks of treatment.

If your INR is above your target range, it will increase your risk of bleeding. While your doctor will help you determine a safe target INR level, a bleeding episode can occur even if your INR is within the therapeutic range. A bleeding episode may be caused by an injury, surgery, or a medical condition such as a stomach ulcer.

Eliquis has been shown to interact with a number of medications, including hormones, certain antibiotics and the thrombolytic drug heparin. It is also not recommended to use heparin-containing clotting agents called clot busters with this medication as they can increase the risk of bleeding.

Aside from avoiding foods that interact with Eliquis, there are no specific diet recommendations for people on this drug. For those with a history of heart disease, however, limiting saturated fat in the diet can help reduce the risk of plaque buildup in arteries and veins that could lead to a heart attack or stroke.

Vitamin E

The natural vitamin E supplements d-alpha tocopheryl acetate and dl-alpha tocopherol may interact with Eliquis. This may cause your blood to become less effective at clotting or cause bleeding in the brain, kidneys, or other organs. If you take these supplements while on Eliquis, talk to your doctor. They might suggest you switch to another supplement or change your dose of Eliquis to avoid these interactions.

Many people taking blood thinners like Eliquis need to follow a diet that doesn’t include foods high in saturated fats. These foods can lead to plaque buildup in the arteries and veins of people with heart disease, which increases the risk of stroke or heart attack.

It’s important to tell your doctor and pharmacist about all the vitamins, herbs, and supplements you take, even those that aren’t prescription. This information can help you avoid drug-drug interactions. Eliquis does interact with some foods, including certain leafy vegetables and cranberry products. It can also interact with some anticoagulants, such as warfarin.

Eliquis can increase your risk of spinal blood clots after certain procedures, such as spinal injections or lumbar punctures (commonly called spinal taps). If you’re scheduled for one of these procedures while on Eliquis, let your doctor know. They might recommend you stop taking the medication for a few weeks before your procedure.

Several other medications interact with Eliquis, including alkylating agents (such as carboplatin) and anti-tumor antibiotics. They can increase your risk of side effects, such as bleeding. It’s also not recommended to take Eliquis during pregnancy or while breastfeeding. The medication can affect your unborn baby and can pass through breast milk. Talk to your doctor if you’re pregnant or nursing before starting this medication.


Garlic (Allium sativum) is an edible plant in the onion family that’s grown for its distinctive taste and claimed health benefits. The plant produces sulfur compounds that have strong biological activity. It’s used today for conditions linked to the heart and blood system, including high cholesterol and high blood pressure.

Some of the purported benefits of garlic are based on its ability to kill bacteria, viruses and fungi. The sulfur compounds allicin and allyl polysulfides in garlic produce these effects. The amount of allicin in a clove of fresh garlic is reduced when the garlic is cooked or aged. Aging also changes the chemical composition of garlic and reduces its smell.

Several studies show that raw or cooked garlic has anti-viral, anti-fungal and antibiotic properties. The odor-reducing allicin is believed to be responsible for these properties, but the chemistry behind this is not entirely understood. Garlic also has antioxidant properties and is thought to prevent certain cancers. However, most research is not conclusive on this topic.

The chemical allicin is a natural anticoagulant and has been shown to reduce the risk of developing clots in the veins of the legs or lungs (DVTs, PE). A study published in “Cancer Prevention Research” found that lung cancer patients with a high intake of garlic had a 44 percent lower risk of death than those who did not eat enough garlic.

Despite its natural anticoagulant action, it’s important not to eat too much garlic because it can cause stomach upset and bad breath. It’s also possible that garlic may interfere with some medications, including the blood thinner warfarin (Coumadin). Talk to your doctor before adding this or any other herbs or supplements to your diet.


Some foods act as natural blood thinners, but they aren’t nearly as potent as prescription anticoagulants. Generally, they can be safely consumed in small amounts, such as in the form of a ginger root or herbal extract. However, it’s important to check with your doctor if you’re taking any other medications that might interact with these blood thinners.

Several studies suggest that ginger can help ease nausea and vomiting associated with pregnancy, including morning sickness. In one study, women who took 1 gram of ginger every day for four days experienced less vomiting than women who didn’t take ginger.

Another benefit of ginger is its ability to reduce bloating and gas. Its astringent properties can tighten the stomach, and its antioxidants can help manage free radicals in the body that cause aging and cell damage.

There is some data suggesting that consuming ginger, ginkgo biloba, turmeric and certain Chinese herbs can increase the risk of bleeding when combined with anticoagulants like apixaban. It’s also important to be careful when taking NSAID medications, such as aspirin and ibuprofen (Advil, Motrin), because they can lead to an increased risk of bleeding when taken with this medication.

Eating a heart-healthy diet can optimize your cardiovascular health while on Eliquis, so it’s worth taking the time to reorganize your pantry and fridge with foods that are safe for you. If you’re having trouble making these changes on your own, consider working with a registered dietitian to learn about how to create delicious meals that are also safe for you while on Eliquis. This will make it easier to stick with your new lifestyle and improve the chances that you’ll be successful in the long run.

Red Clover

Red clover (Trifolium pratense) is a common wildflower in the legume family that also includes peas and beans. Herbalists use it as a treatment for many conditions, including asthma, whooping cough, arthritis and gout. It is most often promoted for menopause symptoms and osteoporosis, but studies have produced mixed results.

The isoflavones found in red clover are similar to the body’s natural estrogen, and they may help reduce hot flashes in menopausal women. However, research suggests that too much estrogen increases breast cancer risk. Other isoflavones in the herb are believed to block an enzyme that raises cholesterol levels and blood pressure.

Women who take high doses of red clover or other isoflavone supplements have reported bloating, a change in their menstrual periods and mood changes. It is also thought that isoflavones could increase the risk of endometrial cancer, which occurs in the lining of the uterus.

Isoflavones from the clover plant are not recommended for pregnant or breastfeeding women. They may interfere with the absorption of certain prescription medications, especially anticoagulants like warfarin. Red clover is also not recommended if you are taking hormones or have hormone sensitive conditions, as it contains phytoestrogens with potential estrogenic and abortifacient properties.

Talk to your healthcare provider before taking any dietary supplement. Eliquis does not interact with most foods, but it is important to maintain a healthy diet while you are on the medication. This can include a balanced diet that is low in saturated fat, trans fat, cholesterol and sodium. It’s also important to drink plenty of water and exercise regularly. Your healthcare provider may refer you to a dietician to help plan your diet.

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